The project is carried out by an interdisciplinary team of researchers, including biochemists, chemists and computer programmers.

We are a part of the Department of Molecular and Systems Biology hosted by the Institute of Bioorganic Chemistry Polish Academy of Science, the top-ranked (A+) Polish research institute in biochemistry. The Department of Molecular and Systems Biology is an interdisciplinary team, led by prof. Marek Figlerowicz. The Department’s experimental research focuses on elucidating the role of RNA in regeneration and cell turnover with the use of biochemistry, molecular biology, cell biology, and computational methods

We constantly publish our research results in peer reviewed journals and at international conferences. Please check the links below.

Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro

Lucyna Budzko, Paulina Jackowiak, Karol Kamel, Joanna Sarzynska, Janusz M. Bujnicki, Marek Figlerowicz; Scientific Reports 7, 2017 doi:10.1038/s41598-017-03936-x

RNA-Seq-based analysis of differential gene expression associated with hepatitis C virus infection in cel culture

Anna Hojka-Osinska, Lucyna Budzko, Agnieszka Zmienko, Agnieszka Rybarczyk, Patrick Maillard, Agata Budkowska, Marek Figlerowicz, Paulina Jackowiak; Acta Biochimica Polonica, vol. 63, 2016

Small RNA fragments derived from multiple RNA classes – the missing element of multi-omics characteristics of the hepatitis C virus cell culture model

Paulina Jackowiak, Anna Hojka-Osinska, Anna Philips, Agnieszka Zmienko, Lucyna Budzko, Patrick Maillard, Agata Budkowska, Marek Figlerowicz; BMC Genomics, 2017 Jun 30;18(1):502

Production of an active human AID enzyme in a bacterial system

Lucyna Budzko, Paulina Jackowiak, Marek Figlerowicz; BioTechnologia vol. 97(3), 2016

Copy number variation of genes involved in the hepatitis C virus-human interactome

Lucyna Budzko, Malgorzata Marcinkowska-Swojak, Paulina Jackowiak, Piotr Kozlowski, Marek Figlerowicz; Scientific Reports 6, 2016 doi:10.1038/srep31340

Phylogeny and molecular evolution of the hepatitis C virus

Paulina Jackowiak, Karolina Kuls, Lucyna Budzko, Magdalena Figlerowicz, Marek Figlerowicz; Infection, Genetics and Evolution, 2013, Nov 4, 21C:67-82

Activation-induced cytidine deaminase (AID): single activity-pleiotropic effect

Lucyna Budzko, Paulina Jackowiak, Marek Figlerowicz; BioTechnologia vol. 94(1), 2013

European Patent no EP2870241
Polish Patent no PL225333
United States Patent Application no US 14/384,665
International Patent Application under the PCT no PCT/PL2014/000003

Lucyna Budzko, Paulina Jackowiak, Marek Figlerowicz „Modified gene of human activation-induced cytidine deaminase (AID), a method of modification of human AID gene, a composition showing AID activity, a method of preparation of such composition in a bacterial system and use of the composition in the analyses of DNA/RNA amination/deamination and/or methylation/demethylation”